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125:582: Nano- and Micro-engineered Biointerfaces
Brief Description: This course introduces methods for engineering biointerfaces on the nano- and
micro-scale. Both synthesis (creating nano-/ micro-scale substrates) and fabrication (preparing
nano- / micro-scale features on substrates) will be covered. Substrates will include ceramics,
polymers, and metals; biological systems will comprise cells, genes, and ligands.
Instructor: Professor Kathryn Uhrich
Wright-Rieman Laboratories, Room 311, Busch
Tel: 732 445 0361, Fax: 732 445 7036
Uhrich@rutchem.rutgers.edu
Office hours: TBA
Integrative Faculty Experts: Professors Yves Chabal, Rick Riman, David Shreiber, Charles Roth,
Prabhas Moghe, Adrian Mann, Larry Romsted, Tom Cook
Prerequisites: Background in undergraduate chemistry, general
biology, physics, and interest in integrative studies of biological interfaces.
Students concerned about their preparation should contact the instructor for
guidance.
Course Outline:
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Topic |
Assignments |
| Week 1 |
Introduction, terminology; Examples of nano- and
micro-scale in biology |
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| Week 2 |
Substrate modification on the micro-scale. Surface
patterning via microlithography |
HW #1 assigned |
| Week 3 |
Substrate modification on the micro-scale. Surface
patterning via microcontact printing; microtexturing;
self-assembled monolayers |
HW #1 due
HW #2 assigned |
| Week 4 |
Substrate modification on the nano-scale. Surface
patterning via phase separation; templating;
nanolithography |
HW #2 due
HW #3 assigned |
| Week 5 |
Substrate modification on the nano-scale. Synthetic
approaches such as chemistry of surface modification;
site-specific chemistry |
HW #3 due
HW #4 assigned |
| Week 6 |
Surface patterning techniques (case studies) : Choosing
an appropriate patterning method and interface |
HW #4 due |
| Week 7 |
Applications such as biosensors; microfluidics,cellbased
bioreactors for metabolic control; gene-based
microarrays |
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| Week 8 |
Formation of micro-scale substrates: microparticles;
microfilms; microfibers |
Report #1 due
HW #5 assigned |
| Week 9 |
Formation of nano-scale substrates. Synthetic
approaches for organic materials to include
dendritic/branched polymers; colloids such as micelles
and liposomes |
HW #5 due
HW #6 assigned |
| Week 10 |
Formation of nano-scale substrates. Synthetic
approaches for inorganic materials |
HW #6 due
HW #7 assigned |
| Week 11 |
Formation of nano-scale substrates. Fabrication
methods to generate nanoparticles; nanotubes and
nanofibers |
HW #7 due
HW #8 assigned |
| Week 12 |
Formation of nano- and micro-sized substrates (case
studies). Choosing the appropriate size scale and
biomaterial |
HW #8 due |
| Week 13 |
Applications such as tissue scaffolds,
gene/drug delivery; drug transport across cellular
membranes |
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| Week 14 |
Critical issues |
Report #2 due |
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Final exam |
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Textbooks: Required: None. Readings will be based on review
papers as well as current literature
Course Projects: Students will prepare two descriptive reports,
one following each course module (module I: substrate modification, weeks 1-8;
module II: substrate synthesis/fabrication, weeks 9-
16). Each report will integrate course material for that module by describing:
a) a relevant biomedical problem, b) fundamental biological principles, c) the
role of interfacial science in the
problem or its potential solution, and d) an engineering approach to its solution.
Topics may be chosen from literature or research projects.
Following most of the lectures (see Course Outline), a short writing assignment
will be given to integrate principles described in the class with the current
literature that
will be due at the beginning of class the following week.
Grading Policy: Homework 30%; Reports 40%; Exam 30%
Objectives: To provide students with fundamental principles
and applications to engineer biological interfaces at relevant size scales.
Specifically, students will learn:
To assimilate the principles and practical overview of the tools applied to
biology, materials science, and engineering for deeper understanding and integrative
design and
development of technologies for emerging applications.
.
Relationship of Course to Program Objectives: This is among
the core courses of the IGERT Training Program on Integratively Engineered Biointerfaces.
As such, there is an emphasis on
interdisciplinary and integrative approaches to the development of biomedical
technologies.
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| MAJOR EVENTS |
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Next IRIF: Wed. April 30th: Research Talk, Jocie Cherry, IGERT Trainee
11:45 am - 1 pm, Room CCR-201 (Note: change of location!)
Congratulations to IGERT Trainee Kevin Nikitczuk,
awarded 2-year pre-doctoral fellowship from New Jersey Commission on Cancer Research for his research "Immune Targeting using an Engineered Vaccine Delivery System", advised by Professors Martin Yarmush and Edmund Lattime
Congratulations to IGERT Trainees Roberto Delgado-Rivera, Salah Hamed, and Christopher Ricupero,
winners of the Best Poster Awards at the Biointerfacial IGERT Symposium on April 11th
IGERT faculty members Roth and Langrana win prestigious Rutgers' teaching awards
Congratulations to: Professor Charlie Roth, selected to receive a Warren L. Susman Award for Excellence in Teaching "for his outdstanding service in stimulating and guiding the intellectual development" of Rutgers students; and to Prof. Noshir Langrana, recipient of a Faculty-
Scholar Teacher Award, which honors faculty members whose research "informs and adds excitement to their teaching and ...stimulates and informs students' scholarship."
Next IRIF: Wed. April 16th: Research Talk, Frances Gratacos, IGERT Trainee
11:45am-1 pm, Room 122, BME Bldg.
Fourth Annual Research Symposium, IGERT on Biointerfaces
Friday April 11, 2008;
8:00 am - 1:30 pm; Busch Dining Hall, Rooms A&B.
Research Talks & Posters by IGERT Trainees; Plenary Talk by Prof. Scott Diamond, U. Penn; [Agenda
and Roster of Talks and Posters]
Next IRIF: Wed. March 26th: Research Talk, Kevin Nikitczuk, IGERT Trainee
11:45 am-1 pm, Room 122, BME Bldg.
Next IRIF: Wed. March 5th: Research Talk, Ronald Perez, IGERT Trainee
Next IRIF's: Feb. 6th: Fellows Networking; Feb 20th: Research talk, Eric Yang, IGERT Trainee.
11:45 am-1:00 pm, Room 122, BME Bldg.
Spring 2008 IGERT Research Interchange Forum (IRIF) Schedule Posted at Meetings/Calendar above.
Next IGERT Research Interchange Forum (IRIF): Tues. Dec. 11; 11:45 AM-1:00 PM; BME-122
Topic: Novel Anionic Block Copolymers for Oligonucleotide Delivery Presenter: Lavanya Peddada, IGERT Trainee
IGERT Alumni Tim Maguire and Eric Novik to participate in GS-NB's
Panelists Tim Maguire (Merck & Co.), Eric Novik (Hurel Corp.), and Bala Subramanian (Goldman Sachs) will discuss early career opportunities for graduate students and postdocs in math, science, and engineering. Monday Nov 26; 5:00 - 6:30 pm; Center Hall, Busch Campus Ctr; sign-up required; call Career Services at (732) 445-6127, ext. 0
Next IGERT Research Interchange Forum (IRIF): Tues. Nov. 13; 11:45 AM-1:00 PM; BME-122
Topic: The Effects of Substrate Rigidity on Synaptogenesis and Dendrite Branching
Speaker: Michelle Previtera, IGERT Trainee
Next IGERT Research Forum (IRIF): Tues. Oct. 16; 11:45 AM-1 PM; BME-122
Topic: IGERT on Biointerfaces: Milestones Crossed and New Challenges Ahead
Presenter: Professor Prabhas Moghe, IGERT Program Director
Next IGERT Research Forum (IRIF): Thurs. August 9; 11:45 AM-1 PM; CCR-201
Topic: Relationship of Chemotherapeutic Dose-Response Curves to Cell Cycle Effects
Presenter: Salaheldin Hamed, IGERT Graduate Training Fellow
IGERT Scholarly Excellence Awards
All IGERT Trainees are actively working toward publications. Jose Fernandez and Matthew Treiser, Cohort II/III trainees leading with the most crossdisciplinary publications, will receive the 2007 IGERT Scholarly Excellence Awards. Charles Florek and Nicole Plourde deserve honorary mention.
NSF EAPSI Fellowship Awarded to Michael Wininger
Congratulations to IGERT Graduate Trainee Mike Wininger, selected for the NSF's 2007 East Asian Pacific Summer Institute and awarded an internship for stem cell research at the National Taiwan University.
Third Annual Symposium, Rutgers NSF IGERT on Biointerfaces
was held on October 20, 2006, featuring presentations by all Trainees and Plenary Lecture by Christopher Chen, MD,PhD; U. Penn. [agenda, talks/posters ]
2006 IGERT Fellowships Awarded
Congratulations to our newest Graduate Training Fellows: Lavanya Peddada, Kevin Nikitczuk, Michelle Previtera and Jocie Harris.
View all major events >>
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| More News |
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IGERT Inaugural Celebration and Research Seminars
Rutgers IGERT on Biointerfaces holds Inaugural Celebration and Research Seminars on January 30, 2004
New IGERT Graduate Fellows
The Fall 2004 class of IGERT Graduate fellows has been announced. To view information about the new fellows, please click here.
NIH Postdoctoral Program
Rutgers has been awarded the first NIH postdoctoral program in Tissue Engineering. Rutgers to house the first NIH-resource center for polymeric biomaterials.
ISURF Launched
New Undergraduate Research Frontiers Program, ISURF launched June 2004
Rutgers awarded IGERT grant
Rutgers has been awarded its first and New Jersey\'s second IGERT Grant.(Rutgers Media Relations)
(Targum Coverage)
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