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125:583 Biointerfacial Characterization

Brief Description: This course introduces students to various physical, chemical, and biological methods of characterizing biointerfaces, broadly defined. Studies are presented in an integrative manner, i.e. integration across size scales of biomolecular organization and across the composition of the interface. Biointerfaces considered include conventional interfaces of biomolecules (e.g., proteins) on artificial substrates, as well as interfaces of submicroscopic and nanoscale particles with biomolecules and living cells.

Instructor: Professor Prabhas V. Moghe
Office: C-230 Engineering
Phone: 445-4951
Email: moghe@rci.rutgers.edu
Office hours: TBA
Integrative Faculty Experts: Professors Nada Boustany; Edward Castner; Yves Chabal; Theodore Madey; David Shreiber; Charles Roth

Prerequisites: Background in undergraduate chemistry, general biology, physics, and interest in integrative studies of biological interfaces. Students concerned about their preparation should contact the instructor for guidance.

Course Outline:
Lecture
Topics
1,2 Definition of Biointerfaces; Overview of Problems and Applications
3,4,5 Spectroscopy – Electron Spectroscopy, Raman Spectroscopy, Single Molecule
Fluorescence Spectroscopy, Interfacial Second Harmonic and Sum Frequency
Generation Spectroscopy
6,7 Surface Energetics: Contact Angle Measurement; Topography Measurements
8,9,10 Morphology Measurements – Optics & Imaging – Confocal, 2-Photon
Microscopy;
11,12 Electron Microscopy; X-ray and Optical Coherence Tomography
13,14 Scale Specific Characterization of Microscopic, Submicroscopic & Nanoscale
Substrates, Micelles/Macromolecules – Light Scattering; Atomic Force
Microscopy
15 Mechanical Compliance Characterization
16 Proteins at Surfaces; Proteomics
17 Gene Expression and Characterization
18,19 Cellular Growth, Adhesion, Migration; Material Biocompatibility and Toxicity
20,21 Cellular Signaling and Intracellular Processes
22,23,24 Integrative Case Study

Textbooks: None required


Course Project (Case Study): Students will be assigned an integrative case study requiring the application of various biointerfacial characterization techniques (structural, chemical, biological).
The case study will integrate course material by describing: a) a relevant biomedical problem, b) fundamental biological principles, c) the role of interfacial science in the problem or its potential
solution, d)an engineering approach to its solution.


Course Lab: The course will not have a formal laboratory period. However, two to three laboratory demonstrations will be arranged during the course of the semester, the concepts from
which will be reinforced via background reading and a homework assignment.


Grading Policy: Homework 20%; Tests 40%; Case Study:40%


Objectives: To provide students with fundamental principles and applications related to the characterization of biological interfaces that are commonly encountered in biotechnology and
biomedicine. Specifically, students will learn: To assimilate the principles and practical overview of the tools applied to biology, materials science, and engineering for deeper understanding and integrative design and development of technologies for emerging applications.


Relationship of Course to Program Objectives: This is among the core courses of the IGERT Training Program on Integratively Engineered Biointerfaces. As such, there is an emphasis on
interdisciplinary and integrative approaches to the development of biomedical technologies.

MAJOR EVENTS

  • Next IRIF: Wed. April 30th: Research Talk, Jocie Cherry, IGERT Trainee
    11:45 am - 1 pm, Room CCR-201 (Note: change of location!)
  • Congratulations to IGERT Trainee Kevin Nikitczuk,
    awarded 2-year pre-doctoral fellowship from New Jersey Commission on Cancer Research for his research "Immune Targeting using an Engineered Vaccine Delivery System", advised by Professors Martin Yarmush and Edmund Lattime
  • Congratulations to IGERT Trainees Roberto Delgado-Rivera, Salah Hamed, and Christopher Ricupero,
    winners of the Best Poster Awards at the Biointerfacial IGERT Symposium on April 11th
  • IGERT faculty members Roth and Langrana win prestigious Rutgers' teaching awards
    Congratulations to: Professor Charlie Roth, selected to receive a Warren L. Susman Award for Excellence in Teaching "for his outdstanding service in stimulating and guiding the intellectual development" of Rutgers students; and to Prof. Noshir Langrana, recipient of a Faculty- Scholar Teacher Award, which honors faculty members whose research "informs and adds excitement to their teaching and ...stimulates and informs students' scholarship."
  • Next IRIF: Wed. April 16th: Research Talk, Frances Gratacos, IGERT Trainee
    11:45am-1 pm, Room 122, BME Bldg.
  • Fourth Annual Research Symposium, IGERT on Biointerfaces
    Friday April 11, 2008; 8:00 am - 1:30 pm; Busch Dining Hall, Rooms A&B. Research Talks & Posters by IGERT Trainees; Plenary Talk by Prof. Scott Diamond, U. Penn; [Agenda and Roster of Talks and Posters]
  • Next IRIF: Wed. March 26th: Research Talk, Kevin Nikitczuk, IGERT Trainee
    11:45 am-1 pm, Room 122, BME Bldg.
  • Next IRIF: Wed. March 5th: Research Talk, Ronald Perez, IGERT Trainee
  • Next IRIF's: Feb. 6th: Fellows Networking; Feb 20th: Research talk, Eric Yang, IGERT Trainee.
    11:45 am-1:00 pm, Room 122, BME Bldg.
  • Spring 2008 IGERT Research Interchange Forum (IRIF) Schedule Posted at Meetings/Calendar above.
  • Next IGERT Research Interchange Forum (IRIF): Tues. Dec. 11; 11:45 AM-1:00 PM; BME-122
    Topic: Novel Anionic Block Copolymers for Oligonucleotide Delivery Presenter: Lavanya Peddada, IGERT Trainee
  • IGERT Alumni Tim Maguire and Eric Novik to participate in GS-NB's
    Panelists Tim Maguire (Merck & Co.), Eric Novik (Hurel Corp.), and Bala Subramanian (Goldman Sachs) will discuss early career opportunities for graduate students and postdocs in math, science, and engineering. Monday Nov 26; 5:00 - 6:30 pm; Center Hall, Busch Campus Ctr; sign-up required; call Career Services at (732) 445-6127, ext. 0
  • Next IGERT Research Interchange Forum (IRIF): Tues. Nov. 13; 11:45 AM-1:00 PM; BME-122
    Topic: The Effects of Substrate Rigidity on Synaptogenesis and Dendrite Branching Speaker: Michelle Previtera, IGERT Trainee
  • Next IGERT Research Forum (IRIF): Tues. Oct. 16; 11:45 AM-1 PM; BME-122
    Topic: IGERT on Biointerfaces: Milestones Crossed and New Challenges Ahead Presenter: Professor Prabhas Moghe, IGERT Program Director
  • Next IGERT Research Forum (IRIF): Thurs. August 9; 11:45 AM-1 PM; CCR-201
    Topic: Relationship of Chemotherapeutic Dose-Response Curves to Cell Cycle Effects Presenter: Salaheldin Hamed, IGERT Graduate Training Fellow
  • IGERT Scholarly Excellence Awards
    All IGERT Trainees are actively working toward publications. Jose Fernandez and Matthew Treiser, Cohort II/III trainees leading with the most crossdisciplinary publications, will receive the 2007 IGERT Scholarly Excellence Awards. Charles Florek and Nicole Plourde deserve honorary mention.
  • NSF EAPSI Fellowship Awarded to Michael Wininger
    Congratulations to IGERT Graduate Trainee Mike Wininger, selected for the NSF's 2007 East Asian Pacific Summer Institute and awarded an internship for stem cell research at the National Taiwan University.
  • Third Annual Symposium, Rutgers NSF IGERT on Biointerfaces
    was held on October 20, 2006, featuring presentations by all Trainees and Plenary Lecture by Christopher Chen, MD,PhD; U. Penn. [agenda, talks/posters ]
  • 2006 IGERT Fellowships Awarded
    Congratulations to our newest Graduate Training Fellows: Lavanya Peddada, Kevin Nikitczuk, Michelle Previtera and Jocie Harris.
  • View all major events >>

    More News

  • IGERT Inaugural Celebration and Research Seminars
    Rutgers IGERT on Biointerfaces holds Inaugural Celebration and Research Seminars on January 30, 2004
  • New IGERT Graduate Fellows
    The Fall 2004 class of IGERT Graduate fellows has been announced. To view information about the new fellows, please click here.
  • NIH Postdoctoral Program
    Rutgers has been awarded the first NIH postdoctoral program in Tissue Engineering. Rutgers to house the first NIH-resource center for polymeric biomaterials.
  • ISURF Launched
    New Undergraduate Research Frontiers Program, ISURF launched June 2004
  • Rutgers awarded IGERT grant
    Rutgers has been awarded its first and New Jersey\'s second IGERT Grant.(Rutgers Media Relations) (Targum Coverage)